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N,N-Dimethylglycine (short: DMG) is an intermediate of choline metabolism. Betaine (metabolized from choline and is a metabolic precursor to dimethylglycine) donates a methyl group to homocysteine to form methionine [1]. By this removal of one methyl group from betaine, dimethylglycine is formed [1]. DMG is often sold commercially as hydrochloride salt (dimethylglycine HCL).
Dimethylglycine’s Effects on Athletic Performance
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Dimethylglycine has been claimed to be an athletic performance enhancer and can be found in various sports supplements. Since dimethylglycine donates methyl groups to transmethylation process it is claimed to improved energy usage. Therefore, it is often marketed and sold as an energiser.
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The interest in dimethylglycine arose from a report indicating that N,N-Dimethylglycine reduces lactic acid concentration in blood in response to surgical stress in animals [2]. Further human and animal studies yielded inconsistent results. Preferences in mac os x. A study on dimethylglycine-treated horses by Moffit et al. [3] reported lower plasma lactate concentrations after treadmill exercise. However, this study raised doubts about dimethylglycines effectiveness due to an unbalanced design used. Rose et al. [4] found no differences in muscle lactate concentrations in horses treated with dimethylglycine and horses receiving placebo.
In trained athletes, Pipes [5] noted a 23,6% increase in time to fatigue after DMG supplementation. In contrast, Gray and Larry [6] reported no significant changes in short-term maximal treadmill performance between the group receiving pangamic acid (calcium gluconate and N, N-Dimethylglycine) and control. No improvements in aerobic and anaerobic performance were also reported when 400 mg of DMG per/kg of body weight was administered to elite basketball players [7]. DMG also failed to improve maximal treadmill exercise to exhaustion in well-trained college women [8]. Authors of this study concluded that there is no evidence to recommend DMG as an ergogenic aid to endurance athletes.
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Dimethylglycine supplementation seems to have little to no effect on athletic performance besides evidence available is limited and conflicting. More well-researched clinical trials should be done before any definitive conclusions can be made.
Other Dimethylglycine Uses
Treatment of Autism
N,N-dimethylglycine has also been reported to be beneficial in children with autism [9]. Kern et al. [9] reported that some children seem to respond positively to the dimethylglycine supplementation but overall behavioural assessments were not significantly different from children receiving placebo. Same was reported by Bolman and assistants [10], however, the weakness of this study is low dosage used in a small number of children. According to available evidence, subjects treated with DMG show little to no difference compared to untreated subjects for treatment of autism spectrum disorder [11].
Immunostimulant Properties
DMG may improve body’s immune system as reported by Graber and others [12]. Results of their study suggest that dimethylglycine supplementation improves humoral as well as cell-mediated immune responses in humans [12].
Side Effects
Very large doses up to 200 mg/kg given to animal models caused no adverse events [7]. This is not surprising as DMG is a natural metabolite which doesn’t build up in the body.
(Other common names: Pangamic Acid, Vitamin B15, Pangamate)
References
- Friesen, Russell W., et al. “Relationship of DMG, choline, and betaine with oxoproline in plasma of pregnant women and their newborn infants.” The Journal of nutrition 137.12 (2007): 2641-2646.
- Meduski, J. W., et al. 1980. “Decrease of lactic acid concentration in blood of animals given N,N-dimethylglycine.” Presented at Pacific Slope Biomedical Conference, Univ. of California, San Diego, (1980) 7-9.
- Moffitt, P., et al. “Venous lactic acid levels in exercising horses fed N, N-DMG.” Proceedings of the 9th Equine Nutrition and physiology Symposium, E., Lansing, Michigan. 1985.
- Rose, R. J., et al. “Effects of N, N-DMG on cardiorespiratory function and lactate production in thoroughbred horses performing incremental treadmill exercise.” Veterinary Record 125.10 (1989): 268-271.
- Pipes, T. V. “The effects of pangamic acid on performance in trained athletes.” Med. Sci. Sports Exercise (1980) 12:98
- Gray, Michael E., and Larry W. Titlow. “The effect of pangamic acid on maximal treadmill performance.” Medicine and science in sports and exercise 14.6 (1982): 424.
- Reza, Attarzadeh Seyed, et al. “The effect of DMG administration on Biochemical Blood Parameters in Youth elite Basketball Players.” (2013) 55-59.
- Brown, H., L. M. Reimnitz, and A. J. Koch. “No Effect of DMG on Maximal Aerobic Power.” The Journal of Strength & Conditioning Research 25 (2011): S109-S110.
- Kern, Janet K., et al. “Effectiveness of N, N-DMGin autism and pervasive developmental disorder.” Journal of Child Neurology 16.3 (2001): 169-173.
- Bolman, William M., and John A. Richmond. “A double-blind, placebo-controlled, crossover pilot trial of low dose DMGin patients with autistic disorder.” Journal of autism and developmental disorders 29.3 (1999): 191-194.
- Rossignol, Daniel A. “Novel and emerging treatments for autism spectrum disorders: a systematic review.” Ann Clin Psychiatry 21.4 (2009): 213-36.
- Graber, Charles D., et al. “Immunomodulating properties of DMGin humans.” Journal of Infectious Diseases 143.1 (1981): 101-105.
DMG or dimethylglycine or Vitamin B-15 is a protein that has been shown to have some powerful health benefits including helping with autism, boosting our immune system, giving a person more energy and stamina, and helping with weight loss, kidney disease, anti-inflammatory, slows the aging process, helps with diabetes, cardiovascular disease and so much more. Mac sounds like vacum cleaner.
What is it made from - Most of the time DMG is made from plant sources and processed from beans and other plants to create a powerful healing agent. And DMG is actually made in the body naturally in small amounts through the Krebs cycle but it breaks down very quickly.
Super Oxygenation and Sports Enhancement - DMG helps the body to utilize more fuel and oxygen thus helping muscles to be powerful and more efficient. It has been said that the Russians where using DMG to make their athletes more powerful for the olympics. And it also helps to decrease lactic acid formation in the body thus making it easy for athletes to go for long periods of time without having aches, pains, and a lack of stamina.
Promotes Hormone Production - DMG also helps the body to produce more hormones and regulate hormones.
Immune System Booster - DMG is a powerful immune system booster and a good anti-fungal agent, antibacterial, and anti-viral agent.
Helps with Diabetes - DMG helps to regulate blood sugar and increases the production of insulin.
Great for Cardiovascular Health - DMG helps to lower cholesterol and trigs and also increases circulation and even helps lower blood pressure.
Slows the Aging Process - DMG also slows the aging process by being a powerful antioxidant, being a powerful adaptogen, and increasing circulation and oxygen utilization.
Chronic Fatigue Syndrome, Fibromyalgia, and Similar Diseases - Some have also found that DMG can help with CFS, fibromyalgia, and other immune mediated diseases.
Anti-inflammatory - DMG is also a good anti-inflammatory agent helping with arthritis, cardiovascular disease, strokes, and even cancer. All disease starts out with inflammation and thus DMG helps to prevent disease in general.
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Helps with Autoimmune Disease - DMG helps to regulate the immune system thus helping with lupus and other autoimmune diseases.
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Great for Neurological Disease - DMG helps to prevent seizures, boosts up hormone and neurotransmitter production, and increases oxygen utilization and circulation.
Autism - There are many people who feel that DMG can help heal autism. Mac ads cleaner app. If you look for testimonials about children being healed of autism with DMG there are lots of them on-line and on youtube.
Cancer - Because DMG is a powerful antioxidant it helps the immune system to fight off the hundreds of cancers that try to take over every day.
Drugs and Alcohol Addiction - There is some evidence that DMG can also help with alcohol and drug addition by lowering cravings.
Helps with Respiratory Disease - DMG also helps the lungs to function better and thus helps with asthma, bronchitis, and lung disease.
Helps with Stress - Being a powerful adaptogen DMG helps the body cope with the rigors of stress, and helps the body produce nutrients the body needs to build tissues.
Helps with Lots of Diseases - And there are so many diseases that DMG can help with— you will find lots of testimonies to this on-line—if you can think of a disease DMG can probably help.
No Side Effects - Taken in normal doses DMG does not have any side effects that we know of. But it should not be taken by women who are pregnant, nursing or extremely young children—unless directed by a health care provider. And DMG should not be taken with any kind of dairy product which negates the effects of DMG.
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Finding - Most health food stores carry DMG or can order it. And DMG can be found on-line by googling 'Buy DMG Supplement' and lots of places will come up including Amazon and Ebay.
Forms - DMG usually comes in tablets that can be swallowed or chewable tablets.
Dose - Most people take from 250 mg to 1,500 mg daily. It's been shown that DMG should be taken for 28 days, and then take a week off, and if needed come back to the supplement. Remember everything has to be processed by our liver even food.. so it's best to be kind to our liver and live a long happy life. And remember we are all different, some people don't do well with some types of antibiotics and others do, and some don't get along with certain anti-depressant medications and others do— and the same goes for herbs and supplements we are all different.
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Testimonials - See testimonials on-line of people who've had great success taking DMG and there are lots of them.. google 'Testimonials for DMG Supplement'.
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Dr. Paul Haider - Master Herbalist
Feel Free to Share - This information is meant to get you started so you can do more research on your own.. dig a little deeper and find what works for you. This article is for educational purposes only, I strongly recommend that you seek advice from your own GP, private doctor, or medical specialist for any ailment, illness, or medical condition. this article not meant to be a scientific analysis in any way, shape, or form.
Dr. Paul Haider – Master Herbalist and Spiritual Teacher for over 25 years, helping people to recover and feel healthy. You can also find Dr. Haider on FB under Dr. Paul Haider, Healing Herbs, and at www.paulhaider.com – feel free to connect with him anytime.
Here is a short video bio - http://www.youtube.com/watch?v=rK6Eg-xlX3U